The Division of Extramural Research and Training at the National Institute of Environmental Health Sciences (NIEHS ) recognizes the need for a translational research framework that 1) represents the full spectrum of the research our grantees conduct, 2) captures all the nuances of environmental health research, especially at the more "basic" end of the research spectrum, 3) provides a common language for describing translational research in the environmental health sciences, and 4) promotes the telling of translational research stories in progress reports and other research documents.
The Division drafted a translational research framework for environmental health sciences, and a series of examples illustrating potential uses of the framework, which are available at: http://partners.niehs.nih.gov/trf. The draft builds upon several published translational research frameworks as well as specific case studies developed from a range of projects supported by the Division.
This RFI targets scientific investigators and other members of the environmental health sciences and translational research communities who are interested in translational research frameworks. Respondents are encouraged to provide their comments (both specific and general) on the proposed framework and case studies that are available http://partners.niehs.nih.gov/trf.
Examples of topics on which input is sought include the following areas:
- Applicability of the proposed translational research framework map to your translational research in environmental health sciences.
- Benefits and/or challenges related to recognizing movement both around a translational research "ring" as well as across translational research "rings" as translational.
- Elements of translational research in environmental health science that are missing from the framework.
- Suggestions for other names of the framework components.
- Other comments on the utility of this framework for guiding, managing or evaluating translational research.
- Case Study 1: Exposure Biomarkers of Polyfluoroalkyl Compounds in Persons Living in the Ohio River Valley - Susan Pinney(162KB)
- Case Study 2: Children's Environmental Health Center - Frank Gilliland(183KB)
- Case Study 3: MtDNA Damage as a Biomarker for Environmental Mitochondrial Toxicity - Tim Greenamyre(167KB)
- Case Study 4: Peripheral BDZ Receptor Biomarker of Neurotoxicity - Tomas Guilarte(151KB)
- Case Study 5: Study DNA repair in preventing MDS and AML after radiation and benzene exposure - Paul E Hasty(152KB)
- Case Study 6: Protein Aggregation and Inflammasome Signaling in Manganese Neurotoxicity - Anumantha Kanthasamy(256KB)
- Case Study 7: Folic Acid Prevention Pathways for ASD in High Risk Families - Rebecca Schmidt(159KB)
Translational Research Story Template
Submitting a Response
Response to this RFI is voluntary. All responses must be submitted by November 18, 2016.
If submitting by email, please send responses to email@example.com. Please include the Notice number NOT-ES-16-011 in the subject line. Please do not include any proprietary, classified, confidential, or sensitive information in your response.